Welcome Guest

Inflammation and cancer: how hot is the link?

Publication ID: 16889756
Reviewer´s rate: 0/10

  •  
  •  
  •  
  •  
  •  
  •  

Authors: Aggarwal (B B), Shishodia (S), Sandur (S K), Pandey (M K), Sethi (G)

Author Address: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. aggarwal@mdanderson.org

Publication: Biochem Pharmacol

Volume: 72 Issue: 11
2006 November

Page start:1605 Page end:1621

Although inflammation has long been known as a localized protective reaction of tissue to irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of function, there has been a new realization about its role in a wide variety of diseases, including cancer. While acute inflammation is a part of the defense response, chronic inflammation can lead to cancer, diabetes, cardiovascular, pulmonary, and neurological diseases. Several pro-inflammatory gene products have been identified that mediate a critical role in suppression of apoptosis, proliferation, angiogenesis, invasion, and metastasis. Among these gene products are TNF and members of its superfamily, IL-1alpha, IL-1beta, IL-6, IL-8, IL-18, chemokines, MMP-9, VEGF, COX-2, and 5-LOX. The expression of all these genes are mainly regulated by the transcription factor NF-kappaB, which is constitutively active in most tumors and is induced by carcinogens (such as cigarette smoke), tumor promoters, carcinogenic viral proteins (HIV-tat, HIV-nef, HIV-vpr, KHSV, EBV-LMP1, HTLV1-tax, HPV, HCV, and HBV), chemotherapeutic agents, and gamma-irradiation. These observations imply that anti-inflammatory agents that suppress NF-kappaB or NF-kappaB-regulated products should have a potential in both the prevention and treatment of cancer. The current review describes in detail the critical link between inflammation and cancer.

URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retriev...

DOI: ISBN: 0006-2952 (Print)

Peer Reviewed: No

If there is any wrong or missing information please Edit this publication

If you are an author of this work feel free to Add a preprint

If you have read or written this manuscript please write a review

Reviewer's rate: 0/10

[Edit] [Discuss]

Contact Us | Site Map | Privacy | Disclaimer | Terms & Conditions

Copyright © 2008.Cell-Penetrating Peptides | Powered by Henry David Herce